1,2-Dioleoyl-3-Trimethylammonium-Propane (DOTAP)-Formulated, Immune-Stimulatory Vascular Endothelial Growth Factor A Small Interfering RNA (siRNA) Increases Antitumoral Efficacy in Murine Orthotopic Hepatocellular Carcinoma with Liver Fibrosis
نویسندگان
چکیده
منابع مشابه
Inhibition of vein graft stenosis with a c-jun targeting DNAzyme in a cationic liposomal formulation containing 1,2-dioleoyl-3-trimethylammonium propane (DOTAP)/1,2- Citation
Background/Objectives—Coronary artery bypass grafting (CABG) is among the most commonly performed heart surgical procedures for the treatment of ischemic heart disease. Saphenous vein graft failure due to stenosis impedes the longer-term success of CABG. A key cellular event in the process of vein graft stenosis is smooth muscle cell (SMC) hyperplasia. In this study, we evaluated the effect of ...
متن کاملA small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics.
Vascular endothelial growth factor (VEGF) plays a critical role during normal embryonic angiogenesis and also in the pathological angiogenesis that occurs in a number of diseases, including cancer. We developed a novel VEGF blockade system using RNA interference. The small interfering RNA (siRNA) targeting human VEGF almost completely inhibited the secretion of VEGF in a human prostate cancer c...
متن کاملdownregulation of vascular endothelial growth factor enhances chemosensitivity by induction of apoptosis in hepatocellular carcinoma cells
0
متن کاملVascular Endothelial Growth Factor Level as a Predictor of Hepatocellular Carcinoma in Liver Cirrhosis Patients
Department of Internal Medicine, Faculty of Medicine, Universitas Pelita Harapan/Siloam Hospital, Lippo Village, Jl. Siloam No.6, Tangerang, Indonesia Mochtar Riady Institute for Nanotechnology, Jl. Boulevard Jenderal Sudirman 1668, Lippo Village, Tangerang, Banten, Indonesia Klinik Hati Prof. Ali Sulaiman, Jl. Cilamaya No. 46, Jakarta Pusat, Indonesia Department of Physiology, Faculty of Medic...
متن کاملA small interfering RNA targeting vascular endothelial growth factor inhibits Ewing's sarcoma growth in a xenograft mouse model.
Angiogenesis plays an essential role in tumor growth and metastasis and is a promising therapeutic target for cancer. Vascular endothelial growth factor (VEGF) is a key regulator in vasculogenesis as well as in angiogenesis. TC71 human Ewing's sarcoma cells overexpress VEGF, with a shift in isoform production from membrane-bound VEGF189 to the more soluble VEGF165. Transfection of TC71 cells wi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Molecular Medicine
سال: 2008
ISSN: 1076-1551,1528-3658
DOI: 10.2119/2008-00003.kornek